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cb839  (Selleck Chemicals)


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    Selleck Chemicals cb839
    Cb839, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 90 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb839/Telaglenastat/pmc12920139-160-35-37
    Average 95 stars, based on 90 article reviews
    cb839 - by Bioz Stars, 2026-09
    95/100 stars

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    other:

    Article Title: Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance
    Article Snippet: The following chemicals were used: ABT263 (S1001, Selleck Chemicals), ABT737 (S1002, Selleck Chemicals), ABT199 (16233, Cayman Chemical), ARV825 (HY-16954, MedChemExpress), JQ1 (HY-13030, MedChemExpress), OTX015 (S7360, Selleck Chemicals), 17-DMAG (S1142, Selleck Chemicals), BPTES (19284, Cayman Chemical), CB839 (S7655, Selleck Chemicals), P5091 (S7132, Selleck Chemicals), RG7112 (S7030, Selleck Chemicals), IMP1088 (HY-112258, MedChemExpress), PCLX-001 (E1217, Selleck Chemicals), nintedanib (S1010, Selleck Chemicals), R406 (S2194, Selleck Chemicals), 25-hydroxycholesterol (HY-113134, MedChemExpress), digoxin (S4290, Selleck Chemicals), procyanidin C1 (HY-N2342, MedChemExpress), gingerenone A (HY-120912, MedChemExpress), fisetin (S2298, Selleck Chemicals), dasatinib (S1021, Selleck Chemicals), quercetin (10005169, Cayman Chemical), DXR (046-21523, FUJIFILM Wako Chemicals), etoposide (341205, Sigma-Aldrich), DAPI (340-07971, Dojindo), Hoechst 33342 (H342, Dojindo), N -acetyl- L -cysteine (013-05133, FUJIFILM Wako Chemicals), BAY876 (S8452, Selleck Chemicals), dapagliflozin (S1548, Selleck Chemicals) and EN6 (S6650, Selleck Chemicals).

    Incubation:

    Article Title: Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes.
    Article Snippet: To induce differentiation, cells were seeded at confluence, cultured with 100 ng/mL BMP2 (Osteopharma, Cat. #CK-B2 or BioLegend, Cat. #767306), 50μg/mL ascorbic acid, and 10mM β-glycerophosphate, and stained with Alcian Blue and Alizarin Red. .. To inhibit energy metabolism, cells were incubated with 10μM CB839 (glutaminase inhibitor, Selleckchem, Cat. # S7655) and 1μM oligomycin (ATP synthesis inhibitor, Adipogen, Cat. # AG-CN2-0517). .. Micromass cultures were also used to analyze matrix deposition and calcification.

    Article Title: Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes
    Article Snippet: To induce differentiation, cells were seeded at confluence, cultured with 100 ng/mL BMP2 (Osteopharma, Cat. #CK-B2 or BioLegend, Cat. #767306), 50 μg/mL ascorbic acid, and 10 mM β-glycerophosphate, and stained with Alcian Blue and Alizarin Red. .. To inhibit energy metabolism, cells were incubated with 10 μM CB839 (glutaminase inhibitor, Selleckchem, Cat. # S7655) and 1 μM oligomycin (ATP synthesis inhibitor, Adipogen, Cat. # AG-CN2-0517). .. Micromass cultures were also used to analyze matrix deposition and calcification.



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    cb839 telaglenastat  (Selleck Chemicals)
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    Selleck Chemicals cb839 telaglenastat
    ( A ) Viability curves showing titration of GS inhibitor, MSO, alone (left panel) or in combination with sub-lethal doses of GLS inhibitor, <t>CB839</t> (right panel) in SW48 cells (low nutrient conditions). Data is presented as mean and standard error. Statistical analyses of Area Under the Curve (AUC) from 3 biological repeats were performed using one-way ANOVA followed by Sidak’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (left * p = 0.04, ** p = 0.005; right **** p ≤ 0.0001, ** p = 0.005). ( B ) Viability curves showing titration of the GLS inhibitor, CB839, alone (left panel) or in combination with sub-lethal doses of the GS inhibitor, MSO (right panel), in SW48 cells (low nutrient conditions). Data is presented as mean and standard error. Statistical analyses of Area Under the Curve (AUC) from 3 biological repeats were performed using one-way ANOVA followed by Sidak’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (left **** p ≤ 0.0001, ** p = 0.0096) (right **** p ≤ 0.0001, * p = 0.014, ** p = 0.003, * p = 0.025). ( C ) Schematic representation of the glutamate-glutamine cycle and the drugs that inhibit the corresponding enzymes in this pathway. ( D ) Survival graphs of SW48 cells treated with single doses of GLS inhibitor (CB839) 100 nM, GS inhibitor (MSO) 2 mM alone or in combination in full media (left panel) and low nutrient media (right panel) conditions. Data represents the mean of 4 biological replicates. Box plots show the median (centre line), interquartile range (box), and whiskers extending to the minimum and maximum values. Statistical analyses were performed using two-way ANOVA followed by Dunnett’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (RPMI WT **** p ≤ 0.0001; G12A ** p = 0.01, **** p ≤ 0.0001; Low nutrients WT * p = 0.014, **** p ≤ 0.0001; G12A *** p = 0.0003, **** p ≤ 0.0001; G12C *** p = 0.0004, **** p ≤ 0.0001; G12D **** p ≤ 0.0001; G12V ** p = 0.0015, **** p ≤ 0.0001). .
    Cb839 Telaglenastat, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb839/Telaglenastat/pmc12795846-42-0-3
    Average 95 stars, based on 1 article reviews
    cb839 telaglenastat - by Bioz Stars, 2026-09
    95/100 stars
    		  Buy from Supplier

    Image Search Results


    ( A ) Viability curves showing titration of GS inhibitor, MSO, alone (left panel) or in combination with sub-lethal doses of GLS inhibitor, CB839 (right panel) in SW48 cells (low nutrient conditions). Data is presented as mean and standard error. Statistical analyses of Area Under the Curve (AUC) from 3 biological repeats were performed using one-way ANOVA followed by Sidak’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (left * p = 0.04, ** p = 0.005; right **** p ≤ 0.0001, ** p = 0.005). ( B ) Viability curves showing titration of the GLS inhibitor, CB839, alone (left panel) or in combination with sub-lethal doses of the GS inhibitor, MSO (right panel), in SW48 cells (low nutrient conditions). Data is presented as mean and standard error. Statistical analyses of Area Under the Curve (AUC) from 3 biological repeats were performed using one-way ANOVA followed by Sidak’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (left **** p ≤ 0.0001, ** p = 0.0096) (right **** p ≤ 0.0001, * p = 0.014, ** p = 0.003, * p = 0.025). ( C ) Schematic representation of the glutamate-glutamine cycle and the drugs that inhibit the corresponding enzymes in this pathway. ( D ) Survival graphs of SW48 cells treated with single doses of GLS inhibitor (CB839) 100 nM, GS inhibitor (MSO) 2 mM alone or in combination in full media (left panel) and low nutrient media (right panel) conditions. Data represents the mean of 4 biological replicates. Box plots show the median (centre line), interquartile range (box), and whiskers extending to the minimum and maximum values. Statistical analyses were performed using two-way ANOVA followed by Dunnett’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (RPMI WT **** p ≤ 0.0001; G12A ** p = 0.01, **** p ≤ 0.0001; Low nutrients WT * p = 0.014, **** p ≤ 0.0001; G12A *** p = 0.0003, **** p ≤ 0.0001; G12C *** p = 0.0004, **** p ≤ 0.0001; G12D **** p ≤ 0.0001; G12V ** p = 0.0015, **** p ≤ 0.0001). .

    Journal: EMBO Reports

    Article Title: FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer

    doi: 10.1038/s44319-025-00641-z

    Figure Lengend Snippet: ( A ) Viability curves showing titration of GS inhibitor, MSO, alone (left panel) or in combination with sub-lethal doses of GLS inhibitor, CB839 (right panel) in SW48 cells (low nutrient conditions). Data is presented as mean and standard error. Statistical analyses of Area Under the Curve (AUC) from 3 biological repeats were performed using one-way ANOVA followed by Sidak’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (left * p = 0.04, ** p = 0.005; right **** p ≤ 0.0001, ** p = 0.005). ( B ) Viability curves showing titration of the GLS inhibitor, CB839, alone (left panel) or in combination with sub-lethal doses of the GS inhibitor, MSO (right panel), in SW48 cells (low nutrient conditions). Data is presented as mean and standard error. Statistical analyses of Area Under the Curve (AUC) from 3 biological repeats were performed using one-way ANOVA followed by Sidak’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (left **** p ≤ 0.0001, ** p = 0.0096) (right **** p ≤ 0.0001, * p = 0.014, ** p = 0.003, * p = 0.025). ( C ) Schematic representation of the glutamate-glutamine cycle and the drugs that inhibit the corresponding enzymes in this pathway. ( D ) Survival graphs of SW48 cells treated with single doses of GLS inhibitor (CB839) 100 nM, GS inhibitor (MSO) 2 mM alone or in combination in full media (left panel) and low nutrient media (right panel) conditions. Data represents the mean of 4 biological replicates. Box plots show the median (centre line), interquartile range (box), and whiskers extending to the minimum and maximum values. Statistical analyses were performed using two-way ANOVA followed by Dunnett’s multiple comparisons test for all comparisons. Only statistically significant p values are shown (RPMI WT **** p ≤ 0.0001; G12A ** p = 0.01, **** p ≤ 0.0001; Low nutrients WT * p = 0.014, **** p ≤ 0.0001; G12A *** p = 0.0003, **** p ≤ 0.0001; G12C *** p = 0.0004, **** p ≤ 0.0001; G12D **** p ≤ 0.0001; G12V ** p = 0.0015, **** p ≤ 0.0001). .

    Article Snippet: CB839 (Telaglenastat) , Selleckchem , Cat#S7655.

    Techniques: Titration